The Effect of X-radiation on the Multiplication of Rickettsia Mooseri in Embryonate Eggs

نویسندگان

  • Donald Greiff
  • Masahiro Chiga
  • Herman T. Blumenthal
  • Henry Pinkerton
چکیده

The multiplication of Rickettsia mooseri in fertile eggs is speeded up and quantitatively increased by single dose x-radiation given either 24 hours before or 48 hours after inoculation. This effect is noted at all dosage levels studied, ranging from 100 to 1500 r. The rickettsiostatic effects of high incubation temperature (40 degrees C.) and of streptomycin are neutralized by radiation, but the rickettsiostatic actions of PABA, penicillin, and aureomycin are not altered. Possible mechanisms of action and implications of the observed effects are discussed.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Effects of X-rays and Beta Rays (tritium) on the Growth of Rickettsia Mooseri and Rickettsia Akari in Embryonate Eggs

The growth of Rickettsia mooseri was accelerated and quantitatively increased in embryonate eggs containing tritium oxide at levels of 180, 90, and 45 mc./egg during the growth period. The eggs of a group containing 22.5 mc./egg showed only a slight increase in the rate of growth of organisms; the infections in the eggs of a group given 11.2 mc./egg did not differ significantly from those of th...

متن کامل

Further Studies on the Effects of X-radiation on the Multiplication of Rickettsia Mooseri in Embryonate Eggs

The effect of x-rays on the growth of rickettsiae in the embryonate egg was investigated. The intensifying effect of x-radiation of the host on rickettsial growth can be attributed to alterations of the cells of the host that persist at least 7 days. The greatest enhancement of the growth of rickettsiae occurred when moderately infected cells were irradiated. These experiments indicate that x-r...

متن کامل

The Effect of X-radiation on the Multiplication of Influenza a Virus in Embryonate Eggs

Groups of embryonate eggs were given 250, 500, 750, and 1000 r of x-radiation. 18 hours later, these 4 groups, together with a control group, were injected intra-allantoically with influenza A virus. Radiation at all dosage levels caused significant changes in the infectivity titre curves during the next 90 hours. The most striking alterations were the prolonged incubation period and the unifor...

متن کامل

Effect of gentamicin on growth of viral, chlamydial, and rickettsial agents in mice and embryonated eggs.

Gentamicin, at concentrations up to 500 mug/ml, showed no effect on the replication, yield, or infectivity of seven viruses or on the agents of psittacosis and meningopneumonitis when grown in mice or embryonated eggs. At the 500 mug/ml level, lymphogranuloma venereum cultures had a slight reduction in infectivity. Rickettsia akari demonstrated susceptibility at the 5 mug/ml level, whereas R. r...

متن کامل

The Effect of X-radiation on the Oxygen Uptake of Embryonate Eggs

Groups of 10 day old embryonate eggs were given 250, 500, 750, and 1000 r of x-radiation, and oxygen consumption determinations were made subsequently at various intervals during a period of 90 hours. In general, the effect of radiation was moderately stimulatory, but after 90 hours the respiratory rates of the 250 and 1000 r groups were well below those of the control groups. The most striking...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The Journal of Experimental Medicine

دوره 97  شماره 

صفحات  -

تاریخ انتشار 1953